GHB/GBL and alcohol both act as GABAergic depressants. In combination the effects don’t add up linearly — they potentiate each other (synergy). GHB’s therapeutic window is already very narrow — even small dose increases sharpen the effect.
Clinically documented consequences:
- Sudden G-lock (unconsciousness) at doses that would still be tolerable on their own
- Respiratory depression with aspiration risk from vomiting
- Even experienced users experience unpredictable courses
There is no antidote. Naloxone doesn’t help. The only care is breathing monitoring and airway management.
We recommend avoiding this combination. If you use it anyway: keep them separate (hours apart), never alone, clearly marked doses (pipette, syringe — never a capful), with someone sober nearby.
GHB emergencies in Berlin are clinically documented and in most cases trace back to mixed use, not to isolated GHB use.