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Dissociative

Dextromethorphan

also: Robo · Robotripping · Dex · Tussin · Triple C · Skittles · Velvet

review pending

Content is undergoing medical and legal review. Changes possible.

Dissociative found in cough medicine. Dose-dependent effects: low doses stimulating, high doses strongly dissociative. NMDA antagonist similar to ketamine.

Onset

45 min

Peak

3 h

Duration

8 h

Half-life

4 h

Routes

oral

Dosing

Common dose: 100 mg

Strong dose: 450 mg

Risks

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    Nausea and vomiting consensus
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    Dangerous with SSRIs (serotonin syndrome) consensus
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    Psychosis at high doses consensus
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    Dangerous additives in cough syrups consensus
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    Overheating consensus
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    Respiratory depression consensus

Safer Use

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    Use DXM-only products (no acetaminophen/guaifenesin) consensus
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    Check for SSRI interactions consensus
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    Plateau dosing: wait 1 week per plateau consensus
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    Stay cool and hydrated consensus
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    Trip sitter for high doses consensus
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    Avoid with MAOIs consensus

Drug Checking

Only use products containing ONLY dextromethorphan HBr. - Avoid combo products with acetaminophen (liver damage) - Avoid guaifenesin (severe nausea) - Check for CYP2D6 interactions