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Opioid

Kratom

also: Mitragyna · Biak · Ketum · Thom

review pending

Content is undergoing medical and legal review. Changes possible.

Natural opioid-like substance from Mitragyna speciosa leaves. Low doses: stimulating. High doses: sedating and analgesic. Partial mu-opioid agonist.

Onset

20 min

Peak

1 h 30 min

Duration

5 h

Half-life

3 h

Routes

oral

Dosing

Common dose: 2 g

Strong dose: 7 g

Risks

  • ·
    Physical dependence develops quickly consensus
  • ·
    Withdrawal similar to opioids consensus
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    Nausea and vomiting consensus
  • ·
    Constipation consensus
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    Liver toxicity with chronic use consensus
  • ·
    Respiratory depression at very high doses consensus

Safer Use

  • ·
    Start low (2-3g) consensus
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    Don't use daily - tolerance builds fast consensus
  • ·
    Rotate strains consensus
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    Stay hydrated consensus
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    Don't mix with other depressants consensus
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    Taper slowly if dependent consensus

Drug Checking

Kratom quality and alkaloid content varies by strain and vendor. - Red strains: more sedating - White strains: more stimulating - Green strains: balanced - Test for contaminants